I do just that. For the 1st 24 hours after I workout (mon, wed, fri), I will eat plenty of carbs. So if it's a Monday workout, I'll eat lots of carbs until Tue evening, and then switch to fatty steak. Wed afternoon lunch will be steak again, until just before my workout when I'll flood my body with carbs again in preparation.
I don't seem to have any problems, but again, I can only get away with this b/c weight lifting greatly increases insulin sensitivity. Otherwise, I couldn't really justify all the carbs, it would lead to insulin resistance.
Ideally though, I think it's still better for the digestive tract to be 100% in ketosis w/ a couple large meals per day, or completely sugar burning with 4-6 small meals per day. The better of the two options being ketosis, as you probably have built up insulin resistance from years of carb overload.
I wouldn't say the differences are too huge, but there is a difference.