the seed hull of the milk thistle is the most medicinal, i agree that it has beneficial properties when eaten as a seed, i enjoy it and find more benefit from it when i grind it up into a flour with a coffee grinder, i am sure the more paleo version of this would be morter and pestle but i am lazy :p.......
you can buy tinctures that are alcohol, if you want to go that route you can do what is called a folk method by i would roughly crushing up the seeds, loading them into a jar and then filling it with alcohol, you have to get some super high quality and proof vodka, or everclear, that works, there is also special types of alcohols specifically for this but you would have to have a supplier in town, cover the crushed up seeds and put a lid on the jar, store it in a cool dry place, shaking it a few times each day for two weeks
i have had friend do this with red wine and different herbs, vinegars work as well too, glycerin is another option but you would have to figure out that method, it may involve heat and also i am not sure the beneficial chemicals in the milk thistle come out with that method.....at any rate i would say grind up those seeds and then chaw down a big mouth full, just chew it forever, i think they are delicious this way and especially with ground meat and egg yolks and some herbs kinda like a weird medicinal raw meat loaf
