Author Topic: Ramblings of a madman...  (Read 109636 times)

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Offline djr_81

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Re: Ramblings of a madman...
« Reply #300 on: May 11, 2018, 10:07:37 am »
I guess 18+ months between posts is a bit excessive. :)

Living life. Eating at least one meal a day raw and truthfully more often than not the second meal is. Just having a hard time sticking to 100% raw. When overloaded with stress from work or life I find myself reaching to more readily available calories like dairy or carbs. Since I have so many allergens this starts a cycle of cravings it takes time to work out of.

I've been doing a lot of reading on the far flung corners of the internet the past few years and have found an interesting kinship with many of the folks out there who have moderate to severe corn allergies. The prevalence of it in (and on) so much we consume is frightening. For example most meat processed in the US is cleaned/wiped down with a corn based vinegar and the soaker pads in the wrapped packages are soaked with corn derived citric acid. Ghosting groups who deal with these issues on a daily basis has given me a lot of insight which helps refine my daily approaches.

For those looking for a input on diet I'm eating two meals, one at 12ish, one at 6ish. 1/3 pound (150 grams) of a moderately fatty grass fed/finished ground beef and up to 1/6 pound (75 grams) beef suet fat. A couple dashes of Redmond's Real Salt as well. Most waters have corn additives in the form of salts or are in corn based plastics. I drink a gallon of water a day from the Poland Spring opaque gallon jugs (like milk jugs). Trying to figure out a way to use a more morally responsible water source but so far none are working for me including my tap. Also drinking a couple cups of coffee a day which I can tell my body does not like but it addresses the constant sleep deficit I run.
Light to moderate exercise at this time. If this goes up I'll probably need to bump the meals to 1/2 pound servings.
Currently overweight at 215ish pounds due to the coffee and the infrequent cooked meals both of which are leading to water retention. Cut both out for a couple months and dropped down below 200 but went back to the coffee when work picked up. For reference fighting weight is 185ish.
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Offline djr_81

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Re: Ramblings of a madman...
« Reply #301 on: January 08, 2020, 10:14:30 am »
And 20 months is even more excessive. :)

Been nursing a flare up of Gout in my foot the last week and thinking about getting all of my shit together as this is really painful. Currently 245 pounds with limited activity to work any of that off. I've eating 1-2 of my 2 meals per day raw zero carb but the meals which haven't been are not great choices. Most are at the far limits of cooked paleo but just barely.

I felt like I needed motivation to refocus my willpower. Spent a couple hours re-reading this journal remembering just how great I can feel living deliberately. I miss a lot of the old faces although it looks like many are no longer around.

I've been eating purely raw paleo the last 6 days. Also knocking back a ton of water to clear out uric acid. As soon as this foot can bear weight again it's back to the gym. Let's see just how powerful this way of eating can be with laser focus and a foot in my ass.  8)
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Offline djr_81

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Re: Ramblings of a madman...
« Reply #302 on: April 08, 2020, 12:40:21 am »
Time for another update. Not nearly as encouraging this time.

I had been struggling with the pain in my feet all of January right up to 2/10. I did try to clean up my diet to strictly zero carb raw paleo (grassfed ground beef and suet fat). I was in constant pain and nursing myself along with NSAIDS (Aleve), icing, and cream for gout. Not having insurance all of this was self diagnosed and addressed the best I could (really regret not going to a doctor sooner). The week before 2/10 was particularly busy and I got very little sleep, lots of coffee, lots of stress, just a perfect storm to crash my system. I spent the weekend fasting and then trying a couple other foods to see if something would help (squash, dandelion greens, beets).

I had what I believe was an acute reaction to histamines on February 10th. I hadn't had any of my meat since Thursday. I had a small meal the morning of the 10th and had all the hallmarks of food poisoning. Cold sweats, racing heart, nausea, disorientation. A number of the signs of an anaphylactic reaction. I felt miserable and had no idea why. After a lot of testing I've had a really good allergist diagnose it as a Mast Cell Activation issue. I haven't been able to eat my grassfed beef (or suet) without a flare and subsequent joint pain in my feet and ankles.

I've been trying to find other safe foods but I've basically been living on a dozen hard boiled eggs every day for the last two months. I think I pushed myself way to hard for way too long and the stress of that as well as dietary indiscretions and 6 weeks of NSAIDS may have wiped out my gut bacteria. A lot of the good bacteria help break down histamine as does DAO in the gut. If my intestinal lining is leaky right now it would explain the extra sensitivity. I'm working my way to try and heal up my guy and repopulate with good bacteria. Hoping the sensitivity lowers as things are healed. I'd love nothing more than to get back to eating raw paleo but it is definitely not working for me right now.

The other really difficult thing that has shown up with all of this is a severely heightened sensitivity to smells. This was slowly building before the acute episode (since at least November) but didn't present as a problem until this whole crash. Now different chemical or strong natural scents can give me trouble breathing, coughing, headaches, sore throat, brain fog, etc. It's not as bad as what I've read some others with Multiple Chemical Sensitivities deal with but it's still really difficult. I'm actually living with my parents right now as I can't deal with the smells at home. We have a dog who is mostly housebroken but did enough damage over the years that I can't tolerate home right now. We pulled all the carpet and OSB subfloor out already. We have an enzyme spray coming this weekend to try and get a handle on it. It's a real pain as I need to carefully research everything to avoid possible scent triggers.

Now looking for insight from the group.
Plan to use "Restore" which is a humic acid solution to help heal the gut lining as well as "Gut Pro" probiotics. Also thinking about using slippery elm to help feed things as a pre-biotic (dried me out some each time I took it but may be worth the discomfort). I have marshmallow root as well as may trial that. I also have N-Acetyl Cysteine to help build Glutathione. Any other recommendations?

As far as the chemical sensitivity I've picked up a copy of a Dynamic Neural Retraining Program. This may help based upon the concept that the sensitivity is from limbic damage in a "fight or slight" state which is reinforcing itself each time it's triggered. The program has exercises to encourage alternate pathways for the processing of the trigger scents and reduce or eliminate the physiologic responses.

Lastly, thoughts on the possibility of mold being a co-factor in this whole thing? We had a spot on our house where the gutter was leaking which caused a hole in the siding. Water got in and caused mold issues in our closets. We had visible fuzzy tan/green mold in our closets, bedroom, and a couple spots elsewhere with poor ventilation. We had a general contractor come out and repair the damage but in hindsight no proper containment was done and we didn't throw out anything that wasn''t mold damaged. This was maybe October.
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Offline Susadele

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Re: Ramblings of a madman...
« Reply #303 on: June 12, 2020, 08:06:11 pm »
Hello djr,
did you ever look into vitamin b6 deficiency? There are some conditions in which the need for b6 is higher than for other people. I am asking because histamine reactions, mast cell activation syndrome, sensitivities, smell sensitivy is all very much related to b6 issues. Ground beef gives reactions to many people with these issues because beef itself is already aged and ground it gives even more surface for histamine buildup.
There is science about it, a not so uncommon issue. Depending on the root cause you will find other common nutrient deficiencies that might be involved in these issues.

Just in case you or anyone else ever considers the above as
ones own issue after researching or maybe even doing some testing on it:
If supplemented, the experts and experienced advice to use the p5p form of b6.
In general I think it is better to solve health issues with whole foods, but I came across more and more people and conditions which question if diet can solve it alone. Still, in my opinion, just with all supplements, caution and listening to the body is necessary.
Here on the forum I think it was PaleoPhil who reported in his journal of his experiences with p5p.
« Last Edit: June 12, 2020, 08:20:04 pm by Susadele »

Offline djr_81

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Re: Ramblings of a madman...
« Reply #304 on: June 14, 2020, 08:38:41 pm »
Hello djr,
did you ever look into vitamin b6 deficiency? There are some conditions in which the need for b6 is higher than for other people. I am asking because histamine reactions, mast cell activation syndrome, sensitivities, smell sensitivy is all very much related to b6 issues. Ground beef gives reactions to many people with these issues because beef itself is already aged and ground it gives even more surface for histamine buildup.
There is science about it, a not so uncommon issue. Depending on the root cause you will find other common nutrient deficiencies that might be involved in these issues.

Just in case you or anyone else ever considers the above as
ones own issue after researching or maybe even doing some testing on it:
If supplemented, the experts and experienced advice to use the p5p form of b6.
In general I think it is better to solve health issues with whole foods, but I came across more and more people and conditions which question if diet can solve it alone. Still, in my opinion, just with all supplements, caution and listening to the body is necessary.
Here on the forum I think it was PaleoPhil who reported in his journal of his experiences with p5p.

Thank you Susadele. My folate (B9) was low when tested (2.4, low is around 4) so I've tried a multi-B which flared anxiety. I'll source just a P5P supplement and see if that's better tolerated. It's interesting in that I've wondered if part of the ongoing issue is anemia. B6 is a cofactor needed for proper red blood cell function. Thanks for the insight. :)

The full scope of the situation is we have confirmed a lot of mold in our home and are working on selecting a company to perform remediation. My wife, dog, and I are no longer living in the home as it is causing marked health issues.

I think I had been treading water dealing with it for a couple years (my guess is the "gout" I thought I had developed is related to inflammation from the mold) but as the mold spread to where we can see colonies it's releasing more MVOCs/Mycotoxins. This triggered development of chemical sensitivities which are turning out to be the most difficult aspect to address. I'm also convinced my gut is damaged/leaky and that's contributing to a Candida overgrowth also perpetuating the cycle. I've read some research indicating Candida may have a synergistic relationship with mold perhaps even feeding on the mycotoxins produced. Possible connections between it and aldehydes from chemicals in the environment too. My fungal skin issue (Tinea Versicolor) which flares when Candida gets bad has also been flaring after mold or chemical exposures.
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Offline Susadele

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Re: Ramblings of a madman...
« Reply #305 on: June 15, 2020, 05:06:58 pm »
Ah ok, so mold probably is the main cause for your issues. Maybe working on that solves the problems and all my writing about b6 doesn't apply to you.

What form of b9 / folate was in that b-supplement? Oftentimes folic acid is used, but some time ago it was identified as harmful (a lot to read about it in the internet) which is why one should use a supplement with the natural form of b9 like folate or methylfolate, if one chooses to take a supplement at all.
The usual form of b6 in your b-complex supplement can also be harmful (again a lot of research about it in the internet). It takes the body a lot of other nutrients like zinc etc. to convert the b6 to its active enzyme form p5p. If you don't have enough of these other nutrients, it builds up in blood etc. Which is why usually p5p is recommended as a supplement. Anyway, just like everything, too much p5p in the cells can cause issues. Which is why I recommended caution with that as well, though it is largely well tolerated.

Did you research on why your b9 levels were low? I don't know about the accuracy of such tests though. Could it me mold related? Was your diet low in b9? Did you take other supplements, medications etc that decreased your b9?
And I'd probably research if the p5p could interfere with b9 status. Or if you are deficient in sth which is neccessary to increase b9.
Maybe you even crave some food high in a certain nutrient that could give you a hint and balance it all out again longterm.

Offline djr_81

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Re: Ramblings of a madman...
« Reply #306 on: June 19, 2020, 09:38:54 pm »
I tried Methylfolate from Jarrow brand. It didn't seem to help.

My diet had been fairly limited the last 10 years. It was a good quality grass-fed/finished ground beef with lots of supplemental suet from the same animals. The occasional organ meat as well. The last 5 years I've had varying degrees of success eating this way but also indulging in various SAD foods. I think the stress of work as well as the mold working on me in the background messed up my gut and made me crave more carbs. This would just perpetuate the issues I had prior to raw paleo (I believe there was issues with Candida as well as leaky gut and food allergies/intolerances).

With my diet basically limited to farm eggs at the moment I'm sure I'm getting deficiencies in a number of things.

I haven't found a good link yet on the low folate and how it is involved with mold. It is used to detox so that's probably the link.
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Offline djr_81

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Re: Ramblings of a madman...
« Reply #307 on: July 15, 2020, 03:11:21 am »
Hello djr,
did you ever look into vitamin b6 deficiency? There are some conditions in which the need for b6 is higher than for other people. I am asking because histamine reactions, mast cell activation syndrome, sensitivities, smell sensitivy is all very much related to b6 issues. Ground beef gives reactions to many people with these issues because beef itself is already aged and ground it gives even more surface for histamine buildup.
There is science about it, a not so uncommon issue. Depending on the root cause you will find other common nutrient deficiencies that might be involved in these issues.

Just in case you or anyone else ever considers the above as
ones own issue after researching or maybe even doing some testing on it:
If supplemented, the experts and experienced advice to use the p5p form of b6.
In general I think it is better to solve health issues with whole foods, but I came across more and more people and conditions which question if diet can solve it alone. Still, in my opinion, just with all supplements, caution and listening to the body is necessary.
Here on the forum I think it was PaleoPhil who reported in his journal of his experiences with p5p.

I'm going to source out the B6 now. Also a good zinc supplement. I've been reading through a ton of stuff and came across Pyyrole Disorder. I'm going to ask my primary if we can do a urine screen to check it out. It basically reads as a textbook for disparate health and mood issues I've dealt with since childhood. It's also directly proportionate with stress wherein elevated stress will lower your other stores until you crash. It also simply explains why I did so well on a muscle meat heavy raw paleo diet. Muscle meat is loaded with B6 and zinc. There seems to be dissension as to the validity of Pyyrole Disorder but it's worth a shot to see if it helps me feel better.

"The common clinical symptoms in patients with pyrrole disorder are anxiety (fear); poor stress tolerance; sensory hypersensitivity to light, sound, smell and/or touch; mood and emotional lability; social anxiety and/or withdrawal; poor dream recall; and commonly, explosive temper and aggression. Clinical signs are pale skin (china doll appearance), stretch marks, and white spots on the nails due to the commonly concomitant zinc deficiency. An adverse reaction to omega-3 fish oil can be an important piece of the past medical history raising clinical suspicion for the presence of pyrrole disorder."
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Offline djr_81

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Re: Ramblings of a madman...
« Reply #308 on: August 04, 2020, 08:17:35 am »
Still trucking but this shit's a bitch. Some days I don't want to wake up but that passes. I've lived through worse than this and I'll do so again. :D

Some thoughts on sulfur deficiency then my thoughts after. Both quotes are by Susan Owens who runs the "Trying Low Oxalates" group on Facebook.

Quote
The signs of sulfur depletion – An essay written in 2001 – Susan Costen Owens

I've been tucked away reading a whole new batch of papers on sulfur deficiency...these are from studies where they ON PURPOSE removed cysteine and methionine from the diet (some leaving 25% in and others taking it down to zero). Adverse results were very rapid and very curiously affected the immune system in exactly the same way as mercury toxicity is reputed to do: impairing natural killer cell activity and T cell function. One study talked about AIDS, a disease involving elevations of non-specific IgE like you see in mercury toxicity. AIDS involves a high urinary loss of sulfate just like autism. They found by supplementing n-acetyl cysteine, that much of the worsening of the disease that did not respond to the drugs we all have heard about could be averted. Success was measured by monitoring the functions I just mentioned in the immune system. In fact, the reason they started this therapy was that they had calculated from the amount of
sulfate being dumped in urine that their patients with AIDS were losing systemically as much as almost five pounds of cysteine from their systems annually. Yikes!

(Some people cannot tolerate N-acetyl cysteine, perhaps because their enzymes that make this conversion are arrested by elevated levels of tumor necrosis factor...a cytokine of inflammation. Several studies looked at alternatives to cysteine, including methionine and something with a long complicated name that goes by the trade name procysteine.)

One of the most measurable effects of sulfur deficiency (from many, many studies) was a loss of glutathione levels in organ systems, and for that reason a lot of the studies looked at ways to restore glutathione levels in various tissues after sulfur starvation. Glutathione is made up of three amino acids, and the critical one for its function is cysteine. The liver has been shown to be the last organ to get deficient in GSH during sulfur starvation, so it starts to horde sulfur in the form of cysteine within GSH. After a certain degree of systemic sulfur starvation, the liver itself will begin to release glutathione into the blood, actually raising the levels in the blood for the benefit of the other organs. This elevation of GSH in the blood is a marker of seriously advanced sulfur deficiency.

One of the most interesting studies found that if they added up the equivalent amount of sulfur that was missing from sulfur-deficient chow by adding in an equivalent amount of inorganic sulfate, then when the animals ate this sulfate-enhanced but sulfur-amino-acid-lacking chow, blood levels of sulfate remained just as low as before, and to their shock, every bit of that added sulfate was immediately dumped into the urine. This was from ORAL inorganic sulfate.

Other studies (many of them) found that inorganic sulfate added to the blood was quite effective at restoring systemic levels of sulfate and was very effective at protecting organs like the liver from sulfate starvation or the toxicity of drugs that require sulfate for detoxication.

Just to emphasize a point, inorganic sulfate added outside the gut apparently effectively restores sulfate levels, but it may not restore glutathione levels, for the body needs sulfur in the form of cysteine to make glutathione. Sulfate is one of several products of cysteine, and so are glutathione and taurine.

Putting this information together suggests that some sort of signal in the intestines is likely to regulate the action of the sulfate transporters in the kidneys. They must be turned ON and highly expressed in order to reabsorb sulfate properly, but having lots of free sulfate in the intestines experimentally turned these transporters OFF, by inference.

In autism, sulfate is being dumped in the urine instead of being reabsorbed DESPITE low plasma levels of sulfate...This means the transporters are mostly OFF, and that the usual rules for sulfate regulation have been broken. The dysregulation of the systemic sulfate regulation may be coming from an inappropriate signal from the intestines, and I think it is quite likely, considering other findings in autism, that the usual trigger for this inappropriate signal may happen when the intestines are inflamed. The cells of the intestine, and the ileum in particular shed sulfated GAGs during inflammation. These GAGS may be broken down by macrophages into
inorganic sulfate...possibly giving the body the impression that there is TOO much sulfate around in the intestines which could lead to an excess, so it needs to dump some.

A study found that if BAL or other sulfhydryl-containing drugs that have been found to diminish the toxicity of acetaminophen (supposedly by supplying the ingredients needed to make sulfate) were used in rats made sulfur deficient by diet, these drugs did not restore organ GSH levels rapidly, as they wished they would. But this same study only looked at very short term change (2 hours) even though other studies made it clear that the whole conversion process takes longer than that to go from cysteine or methionine all the way to a useful end product. Inorganic sulfate, in contrast, once it enters the blood in inorganic form is instantly
bioavailable for cells all over the body to use for detoxication or other sulfation purposes.

This same study also did not look at plasma levels of sulfate or organ levels of sulfate...organic or inorganic. There is some chance sulfate supply may be deemed more urgent than glutathione levels, and the sulfate pathway might have been getting preferential use of the sulfur in these drugs. Obviously, we need another study to iron out that issue, especially to understand all that may be happening when we use sulfur containing alpha lipoic acid to treat symptoms we are assuming are being caused by low-level mercury toxicity. The report I saw from the DAN consensus also casts some doubt that chelation is the only thing going on.

I found another most curious parallel. Last fall I read a study about some factory workers exposed to mercury on the job. They experienced a loss of color vision that was restored in the affected workers a year after they cleaned up the factory of mercury...This improvement came without chelation being in the picture at all.

What amazed me was a parallel study I've found (referenced below) which shows the very same color blindness occurring in simple sulfate deficiency when there was no exposure to mercury at all. In parallel, this color-blindness was completely reversed when sulfur levels were restored.

One thing this slew of studies convinced me of is that restricting sulfur amino acids in the sulfate deficient could really backfire UNLESS the equivalent amount of sulfur is restored in some other way that is tolerated. This chemistry is SO important that the body will break down muscle in order to supply the sulfur it needs when deficient, and this deficiency sets in only DAYS after the diet has been restricted of these critical amino acids.

In studies of imposed sulfate deficiency, the usual marker that indicates that some line has been crossed is when there begins to be either a dramatic weight loss or a failure to be able to gain weight, and a failure of young animals to grow. This type of sudden onset of rapid weight loss was something that happened to the Dartmouth professor who had dimethylmercury poisoning. She did not begin to have ANY SYMPTOMS WHATSOEVER until four months after her exposure to mercury, and her FIRST adverse sign was a rapid weight loss which was followed a full month later by neurological symptoms and then coma and death after they started chelation.

When the body borrows sulfur from its own proteins, it leads to having wimpy muscles, and the rest of the protein (the non-sulfur part) tends to be converted into glucose. If other things are still churning along nicely, but that glucose is not burned off, it can lead to weight gain in FAT at the same time as muscle loss. That may explain why my father who later was cachexic (rapid weight loss) was obese in middle age, and why my sulfate-deficient daughter in her infancy got fat AND hypotonic, and could not grow, all at the very same time. This also may explain why she skinnied down after we started her on regular epsom salts baths, started getting taller, and in the very same time frame began to develop muscle tone and muscle strength.

I do not know the cause of my daughter's sulfur deficiency, but I feel my homework after doing this study in the literature is to be sure that I cover the other angles of sulfur deficiency...ie., making sure that if she cannot use cysteine properly, that I somehow help her get GSH in her system, and that I also make sure she is not taurine deficient. These other important downstream products of cysteine may not be helped by the epsom salts baths.


References:

Eltjo J. Glatzenburg et al: Effects of variation in the dietary supply of cysteine and methionine on liver concentration of Glutathione and "active sulfate" PAPS and serum levels of sulfate, cysteine, methionine and taurine: Relation to the metabolism of acetaminophen. J. NUTR. 113:1363-1383, 1983.

Hartmut Jaeschke and Albrecht Wendel. Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content. Biochemical Pharmacology. Vol. 34, no. 7, pp. 1029-1033, 1985.

Raoul Breitkreutz et al. Improvement of immune functions in HIV infection by sulfur supplementation: Two randomized trials. J Mol. Med (2000) 78:55-62.

Cavalleri A. Gobba F. Reversible color vision loss in occupational exposure to metallic mercury. Environmental Research. 77(2):173-7, 1998 May...." A dose-related subclinical color vision impairment was observed in Hg-exposed workers compared to the referents. Just after the survey, working conditions were improved. Twelve months later the workers were reexamined. Mean HgU was 10.0 microg/g creatinine and in no subjects was the BEI exceeded. Color perception was significantly improved compared to the first examination and, furthermore, no differences were observed between exposed workers and referents. The results add evidence that the color vision loss observed during the first part of the study was related to Hg exposure and, moreover, show that this effect is reversible.

Quote
Essay on the relationship between mercury toxicity and sulfur depletion - 2003
I think the reason for this is that the sulfur chemistry is very gradually depleted by the presence of mercury because of effects on transport. Mercury, which functions as an imposter thiol (but one that cannot produce the benefits of the real McCoy) ends up affecting reabsorption of thiols, disulfides, and sulfate, and keeps them from gaining access to the appropriate compartments in the body. This depletion comprises the very machinery cells use to manage sulfur, because it takes sulfur to manage sulfur. That's worth repeating. IT TAKES SULFUR TO MANAGE SULFUR. So, the more severe the deficiency, the more incapable the body may be to do the appropriate thing with sulfur when it finally gets some.

That is an awfully good reason to never let this problem get bad or worse...but I'm afraid the strategy of cutting out sulfur almost completely to avoid negative responses seen on higher dosages could be a formula for acquiring much more severe problems, and I want to emphasize that you can tell this is probably what is happening if you see ANY losses occurring in lean muscle mass or weight or growth.

So, I reemphasize that starting VERY LOW with sulfur supplements and gradually increasing the dose may be the way to go if you have been severely depleted. The measure of severe depletion, again, is the loss of lean muscle mass, failure to grow if you are a child, and an inability to gain weight in a fashion that is appropriate to your age.

There appear to be some conditions of sulfur deficiency which encourage the loss of lean muscle mass but which do not involve the loss of fat. That may may occur because of excess gluconeogenesis (using protein to make sugar) and may cause a sulfur-depleted person to gain visceral fat (around the middle) but have very little muscle underneath their fat.

As we get more basic scientists to help us know the method and order that things fall apart in deficiency, then we will be much better equipped to know which sulfur support is needed at which step to make gaining back health an orderly and relatively painless process. Unlike a vitamin deficiency, which affects ONE chemical and all of its functions, sulfur depletion affects a myriad of molecules and thus a myriad of regulation.

Those who have been watching the reports on the war in Iraq have probably heard the term "command and control" a lot, and know that the goal of the military in the Coalition is to disable Hussein's command and control while hurting as little of the rest of Iraq as possible. There is a sense in which sulfur's main function is command and control, because it manages so much of the energy metabolism in the mitochondrion, and through sulfated GAGs regulates how chemicals move towards and across membranes, and how mobile cells move across surfaces, and regulates hormones and neurotransmitters and cytokines and all sorts of things. With insufficient "command and control" being provided with sulfur, the organization of the body's chemistry begins to fall apart. In diseases where this accelerates
(where cachexia begins and cannot stop) the complete shutdown of the whole body chemistry is certain if the process does not stop.

Again, the study I think EVERYONE should read to understand how mercury toxicity changes things is the paper written by the doctors of the professor at Dartmouth who spilled dimethylmercury on her hand and got a whopping one-time dose of mercury. She was perfectly fine for two months...so the extremely high levels of mercury which her body was clearing at a reasonable rate, did NOT disable all her enzyme systems, or make her lose brain function. She felt so fine it didn't even occur to her to go to the doctor or to get chelated. But, by the third month, she started losing weight, and she still didn't go to the doctor. (This was likely the sign that her sulfur chemistry was now so depleted that it needed to go borrowing from muscle.) That weight loss continued for another month until finally, she began to have neurological symptoms. Those symptoms scared her into going to the doctor, but amazingly, the MRI's in her brain at that point were still normal! But, in just a couple of weeks after she had been chelated successfully (mercury was coming out in huge quantities), she went into a coma, and soon died,
and at that time her autopsy showed huge changes in brain structure. Her doctors concluded that chelation at the stage where she had come to them (after neurological symptoms appeared) was totally useless. But, they never tried to replete her sulfur chemistry because the idea did not occur to them that sulfur depletion was part of mercury toxicity.

But we in the autism community didn't do like those doctors did, generally. Protocols were set up that included some sulfur repletion, but not particularly with the view that the sulfur depletion was a primary problem. But as things have proceeded, you are seeing doctors more and more including normal physiological forms of sulfur in their methods of treatment.

It is very clear that there are other ways to become sulfur depleted where mercury is not a factor at all, like in chronic infection. It is also clear that the methods that have been used for chelation are likely to do some significant rearranging of the sulfur chemistry, but how that works precisely is still unknown. This issue will be very straightforward to address scientifically if the appropriately trained basic scientists can get the proper funding to see how it works.

Susan

I seem to be exhibiting sulfur deficiency. This presents as an "allergy" but it's the body's response to a nutrient it's low in (I get swelling of hands/feet, anxiety, and breathing distress). At this point there's marked muscle catabolizing going on with probably 60% of my upper muscle mass used up by my body. This is representative of advanced sulfur deficiency. It's picked up in speed the past 3-4 weeks. My best guess is that a combination of factors resulted in a perfect storm that set me up for my current predicament. I've been managing a very stressful construction project for the last three years which gave me sharp stomach pains at times. Additionally my diet strayed from my best choices (added more cooked food especially higher oxalate foods (like French fries) and quite a bit of alcohol. Additionally we had the mold overgrowth in our home which was the nail in my health. This likely drained all/most of my glutathione stores and also kept me from rebuilding them.

I've begun transdermal Glutathione patches. I'm also starting up a multi-vitamin patch and a B-vitamin patch. All with the intent to work around gut issues currently being experienced. All patches are from PatchMD and those I've used had a notable effect. My studying on these topics indicates the B-vitamins are necessary co-factors to both increase uptake and use of sulfur as well as clearing of oxalates from the body which directly compete with said sulfur compounds. Of note is the utilization of B6/P5P in this process as recommended by Susadele previously.

My thinking on this whole topic has been getting fleshed out. I experienced a tremendous boost in my health when I began eating raw paleo 10+ years ago. I believe I had spent a couple years eating low carb then no carb addressing personal issues with oxalates without realizing it. I just felt better without fruits, vegetables, and grains in my diet. I believe I was lower in sulfur than optimal and the eating of raw quality grass-fed beef helped top up my levels over the year. I think this also topped up glutathione stores resulting in my resilience to getting sick and easily bouncing back when I did get sick. I also think the period detox so many of us experience may have been dumping of oxalates from my system.

While thoroughly frustrated with how this whole thing has been I am invigorated to come out the other side not only stronger but with a more robust understanding of my personal underlying issues and maybe add back in some low oxalate plant foods to find nutrition from elsewhere. On the bright side our house has been remediated and we're making slow but steady progress rebuilding from all the work that was done on it.

And the beat goes on. O0
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As you simplify your life, the laws of the universe will be simpler; solitude will not be solitude, poverty will not be poverty, nor weakness weakness.
-Henry David Thoreau

 

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