@Van, Yes, the jury is still out and there will never be total agreement on all aspects of diet, gut microbiome, and health.
I suspect that Ron Rosedale is right about overdosing on protein, but I doubt that overdosing on fat is the answer. VLC Paleo defenders have been telling those struggling on it to just "eat more fat" for years (one dude even has that in his signature at the Caveman forum LOL, which seems to have become remarkably quiet in recent months, interestingly), and it hasn't been working. A more diverse diet seems to be more the way to go, at least for me and others I've seen report benefits from adding Paleo-type foods containing missing prebiotics, starch or carbs back into their diets, bringing them more in line with the diets of Paleo ancestors.
I was breast fed. I've already reported repeatedly that I was given antibiotic treatments in the past, and that I suspect that people who have a history of antibiotic treatment are particularly susceptible to problems on diets low in prebiotics and probiotics, so it would seem that you share my suspicion. The antibiotic-damaged are the canaries in the coal mine. We tend to be the first to be the first to show symptoms (especially those who cook all their meats and don't eat enough organs or fat), but we aren't the only ones. It can take years for the problems with chronic VLC to become apparent. Early benefits are common, which can make it harder to recognize the long-term issues.
One of the common misunderstandings about resistant starch is an assumption that it feeds good and bad bacteria equally. The research and people's reports do not support this assumption. On the contrary, RS reportedly carries the bad bacteria out of the body while feeding the good ones.
The American Gut Human Microbiome Project is not studying just the Hadza, they are studying people all around the world and anyone can contribute their own sample. They are begging VLCers and Paleoists like you to submit your samples. If you think their samples are inadequate, then submit your own. It does cost $99 to get your sample analyzed, unfortunately.
I'm not assuming anything about the HGP's research, just going by what I've read about it and other scientific research, as well as my own experience and that reported by many others. Here are some examples:
http://americangut.org/wordpress/wp-content/uploads/2013/09/module1_Sept_16_small.pdf
Paleo dieters showed a bit higher firmicutes than the general population and Paleo dieters had a lowere level of bacteria known to be inflammatory. LC Paleo dieter Shannon Ford's firmicutes were almost as scarce as Michael Pollen's after he had a course of antibiotics, whereas higher carb Paleo dieter Jeff Leach's were far more abundant.
In case you think that low firmicutes is a good thing, based on a past study that suggested an association with obesity, think again:
"A few years ago, it was thought that if you had a high level of Firmicutes, which is a phylum of bacteria, that it was more predictive of maybe an obese phenotype, and if you had less Firmicutes, you were more likely to be lean, but that turned out not to be true." - Jeff Leach, http://chriskresser.com/you-are-what-your-bacteria-eat-the-importance-of-feeding-your-microbiome-with-jeff-leach
http://humanfoodproject.com/preliminary-characterization-of-the-american-gut-population/
Tim / 23 September 2013
Could you discuss a bit about the Fig 5 fecal graph? Why are you further to the left than ‘Pollan pre’? Could one get much further left than you?
Reply
Jeff Leach / 29 September 2013
Good Q. I eat lots of dietary fiber from a lot of sources. I also eat lots of cellulose – ie, the parts of the plants that many folks discard. So, my higher levels of Firmicutes is being driven by lots and lots of ruminococcus – that is, I look like grazing animals (eg, white rhino!). Pollan has tons and tons of Prevotella – which are part of the Bacteroidetes phylum. Note also, there was data years ago that indicated a high level of Firmicutes was predictive of obesity – that is, more Firmicutes, more junk in the trunk. This has not held up as more data comes in. Me for example, BMI of 25.
...
Tatertot Tim / 21 December 2013
... This young lady just posted her AmGut results and compared to mine–world of difference.
We – similar diets
She – lots of antibiotics
Me – no antibiotics for 10+ years, and megadosing with resistant starch.
My result showed I had 11X the number of bifidobacteria of anyone else–that is amazing when you think about it. All my other phyla/species were in line with a well-diversified gut microbiome. Laura’s showed very restricted growth, hardly any diversity at all.
I’d like to see if ANYONE anywhere has more bifido than I do, resistant starch is a proven builder of friendly gut bugs.
Have a look: http://www.ancestralizeme.com/2013/12/20/my-american-gut-results
"cessation of smoking results in a rise in Firmicutes and Actinobacteria. And I posited that a reasonable assumption is that picking up the smoking habit does the reverse. ...
“Tatertot” Tim’s results, after extended supplementation with Resistant Starch in the form of raw, unmodified potato starch, did not show [high Firmicutes] — he had higher than average Bacteroidetes & lower than average Firmicutes. Michael Pollan and Jeff Leach — plant-lovers both — had the reverse. (But Tim’s reports DID show much higher than average Actinobacteria, specifically Bifidobacteria, which may explain why Resistant Starch is leading to many beneficial effects. I touched on that here and at the end of the smoking study post.)
...the fact that both smoking cessation AND plant consumption lead to this [high firmicutes/bacteroidetes] ratio certainly tips us further toward that conclusion. And there is plenty of more evidence that paints a very convincing picture, in my opinion:
What else do we know about Firmicutes and Bacteroidetes?
Besides the obesity link, I have yet to see anything correlating high firmicutes to disease.
Quite a few disease-specific studies correlate high bacteroidetes to more disease (Type 1 Diabetes, IBD, Obesity, Metabolic Disease)
Firmicutes are almost exclusively gram positive. They do not produce endotoxins, and so they cannot contribute to endotoxin-induced inflammatory disease.
Bacteroidetes are ALL gram negative. All endotoxin producers.
Firmicutes — specifically the butyrate-producing Clostridia clusters — live in the mucosal lining of the intestine. It’s where all the butyrate production is, the preferred energy source for colonocytes. They seem to be the guardians and nourishers of the gut barrier.
Bacteroidetes, conversely, are predominant in the luminal space — the hollow space within the large intestine.
... the actinobacteria/proteobacteria ratio. That’s about as solid of a microbiome health marker as there is [high is believed to be good]. Firmicutes/Bacteroidetes is much shakier — still lots to figure out there.
http://mrheisenbug.wordpress.com/2014/01/07/eating-plants-quitting-smoking-was-i-right-about-firmicutes
The microbiome/brain connection:
http://mrheisenbug.wordpress.com/2014/02/17/gut-bacteria-iq-could-it-really-be/
Colon Cancer Linked to Low Diversity of Gut Bacteria
December 06, 2013
http://www.livescience.com/41767-colon-cancer-gut-bacteria-diversity.html
"colon cancer patients tended to have higher levels of Fusobacterium, a type of bacteria that appears to promote inflammation in the gut, which can fuel cancer growth.
And the patients often had lower levels of Clostridia, a bacterial class that may prevent the development of colon cancer by helping to break down dietary fiber and carbohydrates, according to the study."
http://humanfoodproject.com/can-a-high-fat-paleo-diet-cause-obesity-and-diabetes
...humans are 90% microbe and only 10% human. Humbling.
Spawned by the success and technical achievements of the Human Genome Project, an explosion in our understanding of the role of the microbiome (all the genes of our gut microbiota) in human health has literally flipped modern medicine and the understanding of what makes us sick on its head. Importantly, even though dynamic interactions with our microbiome is conditioned by influences as varied as birthing method (vaginal vs c-section), life time exposure to antibiotics, and general lifestyle choices, diet appears to be driving the species diversity of our microbiota and the much-needed functions they encode.
http://humanfoodproject.com/sorry-low-carbers-your-microbiome-is-just-not-that-into-you/
Depending on whom you talk with, a low carb diet is many different things to many people. I think most misinterpret a Paleo or Primal lifestyle as somehow low carb. It can be, but most folks eat a diversity and quantity of whole plants that exceed that of the average American – often by a long shot. It can sometimes be a little low carb-like due the absence of high caloric foods made from grains. But I often find people who skip grains, sugar and the like as really paying attention to whole plants in their diet – which is, of course, a good thing. But a bona fide low, low carb eater is another animal all together. Whether you draw that line at 25, 50, or 75g a day of carbs, its low I’m afraid from the perspective of your gut bugs. Especially if those carbs contain a limited amount of resistant starch and other dietary fibers – food for gut bacteria.
That said, even though someone who eats as much as 200-500g of carbs a day can still be starving their guts bugs if those foods contain little to now indigestible substrates (fiber), a generic rule of thumb (albeit an ugly measure) is less overall carbohydrates – especially when you start dropping below 75-100g a day – translates into a dramatic drop in the amount of food reaching your colon where the vast majority of your intestinal microbial community resides. (There are exceptions to every rule, but follow my logic for a moment).
When it comes to the health and well being of your gut microbes, nothing matters more than fermentable substrates (You can read about here, here, here, here, here, here, here, here, here – you get the idea). As the rules/tenants of basic microbial ecology go, a reduction in fermentable substrates derived from carbohydrates means less energy sources for the microbes – who depend on host-derived substrates as well, as in the case of mucin-degraders like Akkermansia. As fermentation drops, so to does the byproducts of fermentation which include short chain fatty acids (primarily acetate, butyrate, propionate), organic acids, and gases like hydrogen. All of this can and will dramatically shift the pH of the colonic environment. As it stands in a healthy or normal gut, the pH of the colon changes from proximal to distal end, being more acidic in the proximal (front) end than the tail end – mainly as a function of more rapid fermentation as food items empty from the small intestine. As the pH shifts to being more alkaline from less fermentation, a number of shoes begin to drop (or can).
http://chriskresser.com/you-are-what-your-bacteria-eat-the-importance-of-feeding-your-microbiome-with-jeff-leach
> Diet is only one piece of the formula. Lifestyle is a big component, and again, we see that in hunter-gatherers. Like, in Tanzania we see that men eat much more protein and fat than women, and women eat a lot more fiber and probably resistant starch, so it will be really interesting to see if their microbiomes are different. When we look in the United States, when we look at 1000 men and women in the American Gut Project, they look pretty much the same at the phylum level. There are the same number of Firmicutes, the same number of Bacteroidetes, so there’s no separation between men and women yet. Evolution teaches us that more than likely men probably did consume more protein and fat than women if the Hadza are a good referent, and so we should expect, based on diet, that we should see some differences, but I think what is going to happen is that the environment is the great equalizer. The fact that you share the same water, share the same soil, you’re covered in the same feces and blood of the animals that you consume and the dirt from the plants you dig. I think that ultimately levels the playing field, and that social interaction and that movement of bacteria is very fluid between individuals, the soil, the plants, and especially the animals. So, it’ll be really interesting to see how that shakes out.
> I actually consume a considerable amount of fiber, I personally eat between 50 and 150 grams of fiber a day. I try to consume 20 to 30 species of plants a week if I can. So, I get a huge quantity and diversity. I’m interested in it because fiber is the primary substrate or food, if you will, for bacteria, so if you kind of look at it from an evolutionary perspective, if I was in charge of the USDA and Health and Human Services for a day – which God help us, I’m not… for a lot of reasons! – but if I was in charge of My Plate, which used to be the US Food Pyramid, I would argue that probably the most breathtaking change in the human diet that’s had the greatest impact on not only our microbiome, but our health, I would argue that that’s the drop in the diversity and quantity of dietary fiber. For example, you see in Africa 6-month-old Hadza kids that are being weaned onto food are getting 100 to 200 grams of dietary fiber a day, every day.
It seems that you have made several assumptions. Why not look for the information instead of just guessing about it? Please read up on RS and the HGP before making any more negative assumptions about them and asking questions based on the assumptions. I don't want to end up like Richard and Tatertot, spending countless hours answering endless misguided questions, often over and over again. I encourage folks to do their own digging and if you dig and dig and still can't find answers, then I'll be happy to answer your questions.
Take out the LARGE amounts and replace with adequate amounts and the equation might be wholly different.
It doesn't yet seem clear that GCB actually eliminated all meat aside from bee brood. That's what the vegan propagandist wrote, but Iguana seems to be saying that that was a lie and that GCB actually only did that temporarily, if I understand correctly.
I think GCB, as I've mentioned before is suspect more for this than looking at RS, or maybe we can agree that he was suspect in not looking at both.
Yes, given that he apparently hasn't even discussed RS, it does sound like both excessive protein and deficiency in prebiotics could have been factors, and maybe there were other imbalances in his diet. I agree that the experience of GCB and his wife and other people suggests that the instinctive stop doesn't guarantee that people are avoiding dietary imbalances, especially in the modern environment. As GCB indicated, what he's doing is an experiment, not a guaranteed path to success.
Which is more likely, that our ancestors consumed lots and lots of fat, averaging say the 70-80% or more that some ZCers and VLCers eat, and discarded much of the protein and carbier parts of animal carcasses, and passed up most of the plant foods they came across, over the millions of years of human existence, and presumably the women were mainly hunters as well, or that the women gathered lots of plant foods, including with digging sticks (or antlers), and that various peoples ate a fair amount of plant foods during the year, and savored the carbier parts of animals, so that they didn't need to eat such extremely high levels of animal fat throughout the year? Why would we just assume that "eat more fat" is the answer to nearly every problem?
It seems that in "instincto" we eat the broadest range and variety of foods amongst all types of raw diets.
Yes, some credit is due for that, and you seem to eat a broader range than even most Instinctos, which I suspect is part of the reason for your long term better success.
It puts precisely in a natural way the necessary environmental constraints on us so that a balanced diet and vibrant health might eventually emerge.
Indeed, supermarkets and farmers markets don't have the natural constraints of the wild, therefore we by necessity must use our mental faculties to restore some modicum of those natural constraints. I argued in this forum long ago for not over-relying on the aliesthetic senses. It's heartening to see even GCB moving more in this direction recently.
A similar example of how the constraints at work in the wild led just by themselves to a balanced diet is the phenomenon of the usual and necessary practice of « nose to tail » eating of the animals that were hunted or raised. For instance, muscle is rich in methionine and skin, bone…rich in glycine and so being forced to eat, EVEN IF LESS TASTY, the whole animal results automatically in a balanced glycine to methionine ratio and more generally a balanced nutrition can naturally emerge in this way.
Bingo!
PS I won't come back to the forum. I'm only very temporarily in civilized country with internet. Greetings.
Thanks for honoring us with your input, and may the road go easy with you.
Africans eat much more of it because their staples are tubers and not fruit.
Indeed, and not just Africans. Every nation earth whose RS intake has been sampled has had a significantly higher intake than that of the USA. It seems to be one of the biggest holes in most versions of Instincto and Paleo.